Toxicology
IAD has a well established toxicity profile. Between 1971 and 2005 approximately 1.25 billion tablets have been prescribed with 20 million patients treated, on an average dosing regime of 3g per day for 10 days each. The total adverse drug events recorded were less than 1500.
The only consistently observed drug related side effect is a transient elevation of serum and urine uric acid levels.
Adverse events recorded rarely in clinical studies and post marketing surveillance include:
- Nausea and epigastric discomfort
- Altered Liver function tests
- Itching and rash
- Headaches, vertigo, fatigue and malaise
- Arthralgia
- Diarrhoea, constipation
- Nervousness, drowsiness or insomnia
- Polyuria (increased urine volume)
Contraindications: Where there is a known hypersensitivity to product components or in cases where the patient is presently suffering from gout or elevated uric acid blood levels.
Drug interactions: No relevant drug interactions have been seen in clinical studies to date, though caution should be used with xanthine oxidase inhibitors or uricosuric agents including diuretics.